Lovastatin inhibits visceral allodynia and increased colonic permeability induced by lipopolysaccharide or repeated water avoidance stress in rats

摘要: Abstract Statins have been reported to block inflammatory somatic pain and an anti-cytokine property. Lipopolysaccharide (LPS) or repeated water avoidance stress (WAS) induces visceral hypersensitivity increases gut permeability in rats, which are mediated through proinflammatory cytokine-dependent pathways. Since with increased plays a crucial role the pathophysiology of irritable bowel syndrome (IBS), these above animal models considered simulate IBS. We hypothesized that lovastatin improves symptoms patients IBS by attenuating changes. The threshold visceromotor response (VMR) induced colonic balloon distention was measured for assessment sensation rats. Colonic determined vivo quantifying absorbed Evans blue tissue 15 min using spectrophotometer. Subcutaneously (s.c.) injected LPS (1 mg/kg) reduced VMR after 3 h. Pretreatment (20 mg/kg s.c. daily 3 days) abolished this LPS. Repeated WAS (1 h allodynia, also blocked injection before each session. antinociceptive effect on LPS-induced allodynia reversed mevalonolactone, N G -nitro-L-arginine methyl ester naloxone. Lovastatin LPS- WAS-induced permeability. These results indicate possibility can be useful treating