Long non-coding RNAs in renal cell carcinoma: A systematic review and clinical implications.

摘要: // Ming Li 1 , Ying Wang 2, 3 Liang Cheng 4 Wanting Niu 5 Guoan Zhao 6 Jithin K. Raju 7 Jun Huo Bin Wu Bo Yin Yongsheng Song and Renge Bu Department of Urology, Shengjing Hospital China Medical University, Shenyang, Liaoning 110004, P.R. 2 Nuclear Medicine, The First Affiliated 110001, Radiology, Massachusetts General Hospital, Harvard School, Boston, 02114, USA Pathology Laboratory Indiana University School Indianapolis, IN 46202, Orthopedics, Brigham Women’s VA Boston Healthcare System, 02115, Network Education, Beijing Posts Telecommunications, Hebei, 100088, Clinical 110122, Correspondence to: Bu, email: burg@sj-hospital.org Keywords: renal cell carcinoma, lncRNA, diagnosis, prognosis, therapy Received: November 18, 2016      Accepted: March 20, 2017      Published: April 12, 2017 ABSTRACT Renal carcinoma is one the most common malignancy in adults, its prognosis poor an advanced stage early detection difficult due to lack molecular biomarkers. identification novel biomarkers for RCC urgent meaningful project. Long non-coding RNA (lncRNA) transcribed from genomic regions with a minimum length 200 bases limited protein-coding potential. Recently, lncRNAs have been greatly studied variety cancer types. They participate wide biological processes including biology. In this review, we provide new insight profiling their roles carcinogenesis, emphasize on potential therapy.