Synthesis of 1H-indole-2,3-dione-3-thiosemicarbazone ribonucleosides as antibacterial agents.
作者： Shaymaa E. Kassab , Gehan H. Hegazy , Nahed M. Eid , Kamelia M. Amin , Adel A. El-Gendy
DOI: 10.1080/15257770903459267
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摘要: A new isatin ribonucleoside (3) was synthesized in a good yield by trimethylsilyl trifluoromethanesulfonate (TMSOTf) catalyzed coupling reaction between the silylated nitrogenated base of 1H-Indole-2,3-dione (1) and 1,2,3,5-tetra-O-acetyl-β-D-ribfuranose (2). Thiosemicarbazides 4a–e were utilized prepared to give series 1H-indole-2,3-dione-3-thiosemicarbazone ribonucleosides 5a–e. All compounds tested as antibacterial agents showed slight inhibitory activity against selected bacterial strains.
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