Diagnosis of pancreatic cysts: EUS-guided, through-the-needle confocal laser-induced endomicroscopy and cystoscopy trial: DETECT study

摘要: Background The diagnosis of pancreatic cystic neoplasms (PCNs), which now depends on morphology, cytology, and fluid analysis, is still challenging. A novel confocal laser endomicroscopy probe that can be inserted through a 19-gauge FNA needle allows needle-based (nCLE), the feasibility of nCLE has been reported in PCNs. combination cystoscopy by using through-the-needle fiberoptic with nCLE under EUS guidance may improve Objective To assess feasibility, safety, diagnostic yield the clinical Design prospective study. Setting An academic tertiary referral center. Patients Thirty patients Interventions EUS-guided dual imaging (cystoscopy nCLE) for Main Outcome Measurements Technical safety. Associations findings clinical Results procedure was technically successful exception 1 exchange failure. In 2 (7%), postprocedure pancreatitis developed. Specific features associated mucinous cysts were identified: mucin papillary projections dark rings nCLE. sensitivity of cystoscopy 90% (9/10), 80% (8/10), 100% (10/10) 18 high-certainty patients. Limitations single-center study lack complete pathologic correlation. Conclusion appears to have strong concordance PCN. (Clinical trial registration number: NCT01447238.)