Cigarette smoking is associated with thinner cingulate and insular cortices in patients with severe mental illness.

摘要: Background Magnetic resonance imaging (MRI) studies show reduced cortical thickness in patients with schizophrenia and bipolar disorder. These subtle brain abnormalities may provide insight into illness mechanisms. However, environmental lifestyle-related factors, such as cigarette smoking, contribute to structure changes. Cigarette smoking is highly prevalent severe mental illness. In nonpsychiatric samples, has been associated the anterior (ACC) posterior cingulate cortices, insular cortex (INS), dorsolateral prefrontal orbitofrontal cortex. Methods We examined MRI scans from schizophrenia, other psychotic disorders or disorder healthy controls using FreeSurfer. Results included 506 (49% smokers) 237 (20% our study. found left rostral ACC INS compared nonsmoking patients, but this difference was not among controls. No dose-response relationship between amount of these regions. Among maps along whole surface revealed no effects controls, similar analyses increased age-related thinning occipital lobe smokers nonsmokers. Limitations The causal direction could be determined owing cross-sectional design lack detailed data on addiction history. Conclusion effect should considered