Copper(II)-catalyzed amidations of alkynyl bromides as a general synthesis of ynamides and Z-enamides. An intramolecular amidation for the synthesis of macrocyclic ynamides.

作者： Xuejun Zhang , Yanshi Zhang , Jian Huang , Richard P Hsung , Kimberly CM Kurtz

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摘要: A general and efficient method for the coupling of a wide range amides with alkynyl bromides is described here. This novel amidation reaction involves catalytic protocol using copper(II) sulfate-pentahydrate 1,10-phenanthroline to direct sp-C−N bond formation, leading structurally diverse array ynamides including macrocyclic via an intramolecular amidation. Given surging interest in ynamide chemistry, this atom economical synthesis should invoke further attention from synthetic organic community.

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Copper(II)-catalyzed amidations of alkynyl bromides as a general synthesis of ynamides and Z-enamides. An intramolecular amidation for the synthesis of macrocyclic ynamides.

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Copper(II)-catalyzed amidations of alkynyl bromides as a general synthesis of ynamides and Z-enamides. An intramolecular amidation for the synthesis of macrocyclic ynamides.

来源期刊

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