Therapeutics targeting persistent inflammation in chronic kidney disease

摘要: Systemic inflammation is a condition intrinsically linked to chronic kidney disease (CKD) and its other typical sequelae, such as acquired immune dysfunction, protein-energy wasting (PEW), accelerated vascular aging that promote premature cardiovascular (CVD) infections, the two leading causes of death in CKD patients. Inflammation major contributor complications CKD, inflammatory markers, C-reactive protein pro- anti-inflammatory cytokines, correlate with underlying consequences inflamed uremic phenotype, oxidative stress, endothelial CVD, PEW, are sensitive independent predictors outcome CKD. Therefore, appears be logical target for potential preventive therapeutic interventions patients Putative therapy strategies aiming at preventing improving outcomes span over several areas: (1) dealing source (such cardiovascular, gastrointestinal or periodontal depression); (2) providing nonspecific modulatory effects by promoting healthy dietary habits lifestyle changes; (3) increased use recognized pharmacologic have pleiotropic effects; and, (4) introducing novel targeted anticytokine interventions. This review provides brief update on biomarkers possible approaches targeting milieu