CSF markers for Alzheimer's disease: Total tau, phospho-tau and Aβ42

摘要: SummaryToday we have the first therapeutic compounds for treatment of Alzheimer's disease (AD) e.g. acetylcholine esterase inhibitors and in near future may expect new such as γ- β-secretase inhibitors. This has demanded increased accuracy diagnosis AD thus, among other possible approaches, diagnostic markers cerebrospinal fluid (CSF) become a rapidly growing research field. Especially early course disease, when correct is most difficult, biomarkers would be especially valuable one might to greatest potential being effective. Two defining lesions brains are senile plaques neurofibrillary tangles with β-amyloid (Aβ) tau proteins main components respectively. Aβ secreted body fluids including plasma (CSF). In this paper review CSF AD, focus on their role clinical diagnosis. Reduced levels ...