THE INFLUENCE OF SINGLE DOSES OF PROPYLTHIOURACIL ON THE KINETICS OF IODINE ACCUMULATION BY THE THYROID GLANDS OF NORMAL AND HYPERTHYROID SUBJECTS

摘要: DURING the past decade, broad clinical experience has amply confirmed efficacy of drugs thiouracil series in amelioration thyrotoxicosis (1–6). Studies animals and man have revealed that agents this chemical configuration do not inhibit ability gland to concentrate inorganic iodide, but interfere with synthesize hormone from its substrate (7–11). Throughout period, it been possible directly quantify effect these on thyroidal function, since protein-binding rate, which they affect, could be measured. A new method made measurement rate organification iodide (12). This employed studying quantitatively inhibition produced 18 patients by varying doses propylthiouracil. MATERIAL AND METHODS Euthyroid hyperthyroid individuals, 2 nontoxic goiter, comprised subjects. By a...