Effect of Triple Therapy for Helicobacter Pylori Eradication on Hepatic Encephalopathy: A Randomized Controlled Trial

摘要: Introduction: Helicobacter pylori (H. pylori) infection could potentially contribute to the development and severity of hepatic encephalopathy due strong urease activity in stomach H. infected cirrhotic patients. Objectives: To assess effect triple eradication therapy for on encephalopathy. Design: Open randomized controlled clinical trial with 4 arms. Setting: liver diseases unit Suez Canal University Hospital – tertiary care. Patients Maneuver: Forty four Hp+ (Group 1) 44 Hp- patients 2) [based rapid test gastric biopsy] grade 1 3. Interventions: Triple versus standard treatment group antimicrobial (without Omeprazole) 2 14 days. Main Outcome Measures: Blind assessment before within three days from end treatment. One improvement was considered success. Results: Success rate 18.2% 63.6% (p< 0.001) H positive . While negative success 9.1% 59.1% (P< therapy. not significantly different between or among both groups. Among other factors logistic regression models (OR: 1.03<6.22<37.69, P= 0.047) 2.09<11.42<59.46, 0.02) were significant predictors respective Conclusion: Both only, equally improve outcome management The may be attributed ammonia producing gut flora rather than eradication. adds no benefit (Egypt J. Neurol. Psychiat. Neurosurg., 2007, 44(2): 623-634)