Polyclonal B-cell activators in the study of the regulation of immunoglobulin synthesis in the human system.

摘要: Publisher Summary The development of techniques to study polyclonal activation B cells into immunoglobulin and antibody-producing along with the availability activators that differ in terms their requirements for helper T monocytes propensity activate pro suppressor effectors suppression has been great value defining regulatory cellular interactions control B-cell maturation. Such studies have provided clues suggesting new pathogenic mechanisms disordered synthesis patients immunodeficiency, autoimmunity, malignancy. In many cases when such as Soluble Protective Antigen (SPA), Concanavalin A (Con A), Phytohemagglutinin (PHA) a very high activating precursors are examined, irradiated must be used place unirradiated see activation. This chapter defines stages differentiation series also determines role played by networks immunoregulatory macrophages these maturational events. These brought light underlie certain forms primary immunodeficiency disease, well autoimmune, malignant, allergic disorders. Finally, they providing scientific basis rational strategies treatment diseases. union appropriately presented antigen surface receptors triggers subsequent events, which include proliferation terminal antibody-synthesizing plasma cells. process maturation can activated primates Epstein-Barr virus plant bacterial products termed “polyclonal activators”.