Clinicopathologic and epidemiological characteristics of prognostic factors in post-surgical survival of colorectal cancer patients in Jiangsu Province, China

作者: Said Abasse Kassim , Weiyan Tang , Muhammad Abbas , Shenzhen Wu , Qingdao Meng

DOI: 10.1016/J.CANEP.2019.07.004

关键词:

摘要: Abstract Poor survival among colorectal cancer (CRC) patients has been widely associated with clinico-epidemiological features and treatment regimen. In Jiangsu (China), however, it is not known which one of the prognostic factors explains disparities CRC. This prospective study using 1078 (stages I-IV) that underwent surgery at Hospital, explored relevant affecting prognoses right-side colon (RCC), left-side (LCC) rectal (ReC) patients. Of these cases, 234 (21.7%), 241 (22.4%) 603 (55.9%) were found to have RCC, LCC ReC respectively. Compared LCC, RCC exhibited a greater proportion older patients, poorly differentiated carcinomas, higher T-stage TNM-stage. The overall (OS) for was 60 vs.78 or 77 months respectively (P = 0.030). There no significant differences in OS between across subgroups (P = 0.633). multivariate analysis, had age (>60 vs. ≤60 years, HR = 1.529, P = 0.019), N-stage (N1 N0, HR = 4.056, P = 0.012) M-stage (M1 M0, HR = 3.442, P  HR = 2.199, P

参考文章(52)
Han Liang, Xiao-Na Wang, Bao-Gui Wang, Yuan Pan, Ning Liu, Dian-Chang Wang, Xi-Shan Hao, None, Prognostic factors of young patients with colon cancer after surgery World Journal of Gastroenterology. ,vol. 12, pp. 1458- 1462 ,(2006) , 10.3748/WJG.V12.I9.1458
M J O'Connell, J A Mailliard, M J Kahn, J S Macdonald, D G Haller, R J Mayer, H S Wieand, Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer. Journal of Clinical Oncology. ,vol. 15, pp. 246- 250 ,(1997) , 10.1200/JCO.1997.15.1.246
Hongmei Zeng, Rongshou Zheng, Yuming Guo, Siwei Zhang, Xiaonong Zou, Ning Wang, Limei Zhang, Jingao Tang, Jianguo Chen, Kuangrong Wei, Suqin Huang, Jian Wang, Liang Yu, Deli Zhao, Guohui Song, Jianshun Chen, Yongzhou Shen, Xiaoping Yang, Xiaoping Gu, Feng Jin, Qilong Li, Yanhua Li, Hengming Ge, Fengdong Zhu, Jianmei Dong, Guoping Guo, Ming Wu, Lingbin Du, Xibin Sun, Yutong He, Michel P Coleman, Peter Baade, Wanqing Chen, Xue Qin Yu, Cancer survival in China, 2003–2005: A population‐based study International Journal of Cancer. ,vol. 136, pp. 1921- 1930 ,(2015) , 10.1002/IJC.29227
Toru Nawa, Jun Kato, Hirofumi Kawamoto, Hiroyuki Okada, Hiroshi Yamamoto, Hiroyuki Kohno, Hisayuki Endo, Yasushi Shiratori, Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology. Journal of Gastroenterology and Hepatology. ,vol. 23, pp. 418- 423 ,(2008) , 10.1111/J.1440-1746.2007.04923.X
Xuhui Zhou, Zhonghua Su, Huiqiong Deng, Xiaojun Xiang, Hongxian Chen, Wei Hao, A comparative survey on alcohol and tobacco use in urban and rural populations in the Huaihua District of Hunan Province, China. Alcohol. ,vol. 39, pp. 87- 96 ,(2006) , 10.1016/J.ALCOHOL.2006.07.003
Edoardo Botteri, Simona Iodice, Sara Raimondi, Patrick Maisonneuve, Albert B. Lowenfels, Cigarette Smoking and Adenomatous Polyps: A Meta-analysis Gastroenterology. ,vol. 134, pp. 388- 395 ,(2008) , 10.1053/J.GASTRO.2007.11.007
Aleksander Galas, Jan Kulig, Low-grade dietary-related inflammation and survival after colorectal cancer surgery. Journal of Cancer Research and Clinical Oncology. ,vol. 140, pp. 1517- 1525 ,(2014) , 10.1007/S00432-014-1711-6
Frank Benedix, Rainer Kube, Frank Meyer, Uwe Schmidt, Ingo Gastinger, Hans Lippert, COMPARISON OF 17,641 PATIENTS WITH RIGHT- AND LEFT-SIDED COLON CANCER: DIFFERENCES IN EPIDEMIOLOGY, PERIOPERATIVE COURSE, HISTOLOGY, AND SURVIVAL Diseases of The Colon & Rectum. ,vol. 53, pp. 57- 64 ,(2010) , 10.1007/DCR.0B013E3181C703A4