miRNAs and Long-term Breast Cancer Survival: Evidence from the WHEL Study.

摘要: Background: There is substantial variation in breast cancer survival rates, even among patients with similar clinical and genomic profiles. New biomarkers are needed to improve risk stratification inform treatment options. Our aim was identify novel miRNAs associated quantify their prognostic value after adjusting for established factors markers. Methods: Using the Women9s Healthy Eating Living (WHEL) cohort >15 years of follow-up archived tumor specimens, we assayed PAM50 mRNAs 25 using Nanostring nCounter platform. Results: We obtained high-quality reads on 1,253 samples (75% available specimens) used an existing research-use algorithm ascertain subtypes scores (ROR-PT). identified significantly outcomes then tested these independent TCGA samples. that were also further evaluated multiple regression Cox models. penalized unbiased discovery. Conclusions: Two miRNAs, 210 29c, WHEL studies improved within groups: 10-year 62% node-negative high miR-210-high ROR-PT group versus 75% low miR-210- group. Similar results miR-29c. three additional 187-3p, 143-3p, 205-5p, via regression. Impact: findings suggest might be long-term stratification. Further research incorporate into clinicogenomic signatures needed.