Current Status of Time-Lapse Microscopy for Embryo Selection

摘要: One of the major barriers in vitro fertilization (IVF) over past three decades has been decreasing rate multiple pregnancies. Multiple approaches have taken an attempt achieve better embryo selection, including time-lapse microscopy (TLM). This technology allows for evaluation morphology more detail than conventional observation at static time points, as well definition morphokinetics (i.e., precise timing specific morphologic occurrences). So far, 20 morphokinetic markers identified with use TLM; however, most these not thoroughly validated prospective or randomized controlled studies. Furthermore, inconsistencies definitions make it difficult to compare various studies and draw sound conclusions. Because limitations, we do think are currently a position weigh true benefit using TLM until sufficient high-quality evidence exists, believe that should continue be considered experimental subject institutional review approval.