Setting up for gastrulation: D. melanogaster.

摘要: Drosophila melanogaster embryos develop initially as a syncytium of totipotent nuclei and subsequently, once cellularized, undergo morphogenetic movements associated with gastrulation to generate the three somatic germ layers embryo: mesoderm, ectoderm, endoderm. In this chapter, we focus on first phase in involving patterning early when cells differentiate their gene expression programs. This process requires coordination multiple developmental processes including genome reprogramming at maternal-to-zygotic transition, combinatorial action transcription factors support distinct expression, dynamic feedback between genetic by changes cell morphology. We discuss regulatory programs acting during specify layers, which involve regulation spatiotemporal coupled physical tissue morphogenesis.