Mutation Pattern of Hepatitis C Virus and Its Application to Therapy
作者： Masashi Mizokami , Tatsunori Nakano , Etsuro Orito
DOI: 10.1007/978-4-431-68488-6_6
关键词:
摘要: Chronic hepatitis C is a common disease worldwide and major cause of chronic liver in many countries. However, the current standard therapy with interferon (IFN) rather unsatisfactory [1–3]. Therefore, search for additional therapies needs to be pursued. Molecular evolutionary analysis has been applied numerous studies virus (HCV) given informative suggestions. it not yielded helpful information developing effective antiviral drugs against HCV infection.
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Takashi Gojobori, Wen-Hsiung Li, Dan Graur, Patterns of Nucleotide Substitution in Pseudogenes and Functional Genes Journal of Molecular Evolution. ,vol. 18, pp. 360- 369 ,(1982) , 10.1007/BF01733904
Takashi Gojobori, Kazushige Ishii, Masatoshi Nei, Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide. Journal of Molecular Evolution. ,vol. 18, pp. 414- 422 ,(1982) , 10.1007/BF01840889
T. Shirasaka, M. F. Kavlick, T. Ueno, W. Y. Gao, E. Kojima, M. L. Alcaide, S. Chokekijchai, B. M. Roy, E. Arnold, R. Yarchoan, Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 2398- 2402 ,(1995) , 10.1073/PNAS.92.6.2398
R L Carithers, S S Emerson, Therapy of hepatitis C: Meta-analysis of interferon alfa-2b trials Hepatology. ,vol. 26, ,(1997) , 10.1002/HEP.510260715
G C Farrell, Therapy of hepatitis C: interferon alfa-n1 trials. Hepatology. ,vol. 26, ,(1997) , 10.1002/HEP.510260717
Etsuko N. Moriyama, Yasuo Ina, Kazuho Ikeo, Nobuaki Shimizu, Takashi Gojobori, Mutation pattern of human immunodeficiency virus genes Journal of Molecular Evolution. ,vol. 32, pp. 360- 363 ,(1991) , 10.1007/BF02101275
Makoto Hijikata, Nobuyuki Kato, Yuko Ootsuyama, Masanori Nakagawa, Shogo Ohkoshi, Kunitada Shimotohno, Hypervariable regions in the putative glycoprotein of hepatitis C virus. Biochemical and Biophysical Research Communications. ,vol. 175, pp. 220- 228 ,(1991) , 10.1016/S0006-291X(05)81223-9
The neighbor-joining method: a new method for reconstructing phylogenetic trees. Molecular Biology and Evolution. ,vol. 4, pp. 406- 425 ,(1987) , 10.1093/OXFORDJOURNALS.MOLBEV.A040454
O Ohno, M Mizokami, R R Wu, M G Saleh, K Ohba, E Orito, M Mukaide, R Williams, J Y Lau, New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a. Journal of Clinical Microbiology. ,vol. 35, pp. 201- 207 ,(1997) , 10.1128/JCM.35.1.201-207.1997
N. Enomoto, M. Kurosaki, Y. Tanaka, F. Marumo, C. Sato, Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis Journal of General Virology. ,vol. 75, pp. 1361- 1369 ,(1994) , 10.1099/0022-1317-75-6-1361