Within herd transmission and evaluation of the performance of clinical and serological diagnosis of foot-and-mouth disease in partially immune cattle herds

摘要: The control of foot-and-mouth disease (FMD) in vaccinated populations relies upon surveillance activities such as clinical inspections (CI) and serological monitoring. New evidence to refine current guidelines has been provided by evaluating (1) the diagnostic performance CI tests for detection FMD virus (FMDV) non-structural proteins (NSP), (2) within-herd transmission partially immune cattle. Data came from 23 affected herds during an epidemic FMDV type O Bolivia, 2007. All cattle (n=957) these were clinically inspected serum samples collected one month after last animal with signs was detected. Samples tested presence antibodies against NSP using PANAFTOSA 3ABC-ELISA test a subset enzyme-linked immunoelectrotransfer blot assay (EITB). diagnoses analysed Bayesian model. sensitivity Se specificity Sp tests, well prevalence reproduction ratio R estimated. In addition, risk factors infection identified. CI, EITB estimated be 0.30, 0.88 0.96 respectively. Sp, same order, 0.88, 0.93 0.97. infected animals ranged 0.04 0.91 1.02 2.68. It observed that coming areas high vaccination coverage had lower becoming than home-bred herds, where thought low. Although estimates come kept under specific conditions, they provide reference future design can inform simulation models similar populations.