Bridging defects in chronic spinal cord injury using peripheral nerve grafts combined with a chitosan-laminin scaffold and enhancing regeneration through them by co-transplantation with bone-marrow-derived mesenchymal stem cells: Case series of 14 patients
作者： Sherif M. Amr , Ashraf Gouda , Wael T. Koptan , Ahmad A. Galal , Dina Sabry Abdel-Fattah
DOI: 10.1179/2045772312Y.0000000069
关键词:
摘要: AbstractObjectiveTo investigate the effect of bridging defects in chronic spinal cord injury using peripheral nerve grafts combined with a chitosan-laminin scaffold and enhancing regeneration through them by co-transplantation bone-marrow-derived mesenchymal stem cells.MethodsIn 14 patients paraplegia caused injury, were grafted cells injected into whole construct contained paste. Patients evaluated International Standards for Classification Spinal Cord Injuries.ResultsChitosan disintegration leading to post-operative seroma formation was complication. Motor level improved four levels 2 cases two 12 cases. Sensory-level six cases, five three A four-level neurological improvement recorded two-level occurred The American I...
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