Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome

摘要: Lymphocytes from 18 patients with the Wiskott-Aldrich Syndrome (WAS) were examined by scanning electron microscopy (SEM). Most peripheral blood lymphocytes normal individuals are covered slender microvillus projections, but a large proportion of WAS found to be relatively devoid microvilli. A lymphocyte morphology scoring system was developed quantify density microvilli: Grade 4 classified those greater than 75% surface microvilli progressive decrements grade 1, which without The mean score eight 3.62 +/- .22. substantially lower (2.89 .27, P less .001). In addition, often qualitatively abnormal, short, blunted These morphological criteria used diagnose cord one “at-risk” patient. Thus, is first primary immunodeficiency in abnormalities have been identified that can aid diagnosis.