作者: Alfred S. Ketcham , Robert C. Hoye , Paul B. Chretien , Kirkland C. Brace
DOI: 10.1016/0002-9610(69)90214-1
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摘要: Abstract A clinical study of preoperative irradiation was established as a result experimental studies which indicated that local recurrence and metastases could essentially be eliminated by administering irradiation. Using single 2,000 or 1,500 r dose twenty-four hours before surgery, there high incidence complications. Seventy-nine patients were then studied in carefully controlled double-blind using 1,000 preoperatively. All lesions squamous cell cancers the oral pharyngolaryngeal area excised standard but aggressive surgical procedures. The postoperative complications significantly increased with Although definite trend toward decrease irradiation, no statistically significant rate operative wound, nor any tendency metastases; neither patient survival prolonged. gave results again tumors human subjects do not necessarily behave expected on basis tumor systems.