Hepatitis C virus in the new era: Perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy

摘要: Despite the great successes achieved in fields of virology and diagnostics, several difficulties affect improvements hepatitis C virus (HCV) infection control eradication new era. New HCV infections still occur, especially some poorest regions world, where is endemic long-term sequelae have a growing economic health burden. An vaccine no available, despite years researches discoveries about natural history host-virus interactions: candidates been developed last years, targeting different antigens or using alternative delivery systems, but viral variability adaption ability constitute major challenges for development. Many antiviral drugs therapy are preclinical early clinical development, limitations treatment validity. Treatment predictors important tools, as they provide guidance management patients with chronic infection: particular, role host genomics outcomes era direct-acting antivirals may evolve therapeutic targets, representing chance modulated personalized management, when also very potent therapies will be available. In present review we discuss most recent data epidemiology, perspectives prevention evidence regarding diagnosis, response to it.