Magnetic particle imaging performance of liposomes encapsulating iron oxide nanoparticles

摘要: Abstract Magnetic Particle Imaging (MPI) is a new imaging modality that quantifies spatial distribution of superparamagnetic iron oxide nanoparticles in field view through their non-linear magnetization response to an applied magnetic field. Liposomes loaded with (magnetoliposomes) are potential theranostic drug carriers can combine properties carrier ability. Prior work suggests MPI signal be affected by dipolar interactions between close proximity – for instance, polymer matrix. Here we evaluate if encapsulating liposomes has impact performance. For this purpose, magnetoliposomes were prepared using charge-stabilized (IONPs) and physical, characterized. Interestingly, encapsulation IONPs led increase per unit mass.