Curcumin downregulates p38 MAPK-dependent X-ray repair cross-complement group 1 (XRCC1) expression to enhance cisplatin-induced cytotoxicity in human lung cancer cells
作者： Chun-Liang Tung , Yi-Jun Jian , Jyh-Cheng Chen , Tai-Jing Wang , Wen-Ching Chen
DOI: 10.1007/S00210-016-1235-5
关键词:
摘要: Cisplatin is a well-studied and widely used chemotherapeutic agent effective in the treatment of advanced human non-small cell lung cancer (NSCLC). Curcumin yellow pigment derived from rhizome Curcuma longa has been proved to have antioxidant antitumor properties. XRCC1 an important scaffold protein involved base excision repair plays role development cancer. In this study, we characterize curcumin cytotoxicity, p38 MAPK activation, expression affected by cisplatin NSCLC cells. We show that enhanced cytotoxicity induced two cells, A549 H1703. Treatment with alone increased mRNA through activation. Moreover, SB2023580 (p38 inhibitor) decreased stability upon treatment. Knockdown cells transfection siRNA or inactivation resulted enhancing growth inhibition cisplatin. inhibited cisplatin-exposed Furthermore, constitutive active MKK6 HA-p38 vectors rescued level also survival suppressed combination H1703 These findings suggested downregulation can enhance chemosensitivity
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