TGF-β and Inhibitory Smads in Inflammation
作者： Seong-Jin Kim , Seok Hee Park
DOI: 10.1007/978-4-431-54409-8_12
关键词:
摘要: TGF-β is a multifunctional cytokine involved in diverse cellular functions, including cell growth, apoptosis, and immune responses, although its effect likely to be dependent on context. Among variety of functions exerted by TGF-β, recent advances emphasize the importance signaling pathway innate immunity adaptive immunity. The typical examples regulations include suppression toll-like receptor (TLR) which recognizes invading pathogens T differentiations such as Th17 Treg. In particular, much attention has been paid anti-inflammatory function mediated inhibitory Smads, Smad6 Smad7. this review, we mainly discuss role suppressing inflammatory responses underlying mechanism Smads.
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