Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging.
作者： Shu-Wei Sun , Hsiao-Fang Liang , Anne H. Cross , Sheng-Kwei Song
DOI: 10.1016/J.NEUROIMAGE.2007.11.049
关键词:
摘要: Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of may provide better understanding evolution CNS In this study, 28-day longitudinal vivo DTI optic nerve (ON) and tract (OT) was conducted to evaluate temporal spatial resulting from transient retinal ischemia. At 3 − 28 days after ischemia, ipsilateral ON contralateral OT showed reduction axial diffusivity (32 40% 21 29% respectively) suggestive axonal damage. Both increase radial diffusivity, 200 290% 58 65% respectively, at 9 myelin Immuohistochmistry phosphorylated neurofilament (pNF) basic protein (MBP) performed assess integrities validating findings. immunohistochemistry detected that ischemia caused more severe damage than OT. The current results suggest diffusivities are capable reflecting severity mice as assessed using immunohistochemistry.
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