A Porphyrin Pathway Impairment Is Responsible for the Phenotype of a Dominant Disease Lesion Mimic Mutant of Maize

摘要: The maize lesion mimic gene Les22 is defined by dominant mutations and characterized the production of minute necrotic spots on leaves in a developmentally specified light-dependent manner. Phenotypically, lesions resemble those that are triggered during hypersensitive disease resistance response plants to pathogens. We have cloned using Mutator-tagging technique. It encodes uroporphyrinogen decarboxylase (UROD), key enzyme biosynthetic pathway chlorophyll heme plants. Urod humans also cause metabolic disorder porphyria, which manifests itself as light-induced skin morbidity resulting from an excessive accumulation photoexcitable uroporphyrin. phenotypic genetic similarities between porphyria along with our observation associated uroporphyrin revealed what appears be case natural