Silencing Aurora A leads to re-sensitization of breast cancer cells to Taxol through downregulation of SRC-mediated ERK and mTOR pathways
作者： Yan Li , Wanqi Zhou , Ke Tang , Xiaoguang Chen , Zhiqiang Feng
DOI: 10.3892/OR.2017.5908
关键词:
摘要: While Taxol has been reported to improve the clinical survival of breast cancer patients, subsequently developed drug-resistance cells limits its final efficacy and applications. Previous studies suggested that Aurora A is involved in development Taxol-resistance cancer. We established Taxol-resistant MCF-7/T xenograft models explore role resistant ER-positive Compared with their parental MCF-7/C cells, exhibited enhanced colony formation, less cell death higher invasive ability. The presented overexpressed A, elevated phosphorylated SRC upregulated Ras/Raf/ERK Akt/mTOR pathways. Silencing reduced activity downregulated ERK pathways, which led re-sensitization vitro. These results activation subsequent upregulation Akt through induced inhibiting related SRC/EKT/Akt pathway could restore sensitivity Taxol. might shed light on strategies circumvent Taxol-related chemoresistance practice.
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