作者: A. A. Dandekar , S. Chugani , E. P. Greenberg
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摘要: The opportunistic pathogen Pseudomonas aeruginosa uses a cell-cell communication system termed “quorum sensing” to control production of public goods, extracellular products that can be used by any community member. Not all individuals respond quorum-sensing signals and synthesize goods. Such social cheaters enjoy the benefits secreted cooperators. There are some P. cellular enzymes controlled quorum sensing, we show sensing–controlled expression such private goods put metabolic constraint on cheating prevent tragedy commons. Metabolic provides an explanation for private-goods regulation cooperative has general implications population biology, infection control, stabilization circuits in synthetic biology.