Further delineation of molecular alterations in adreno-medullary tumors
作者： Janos Geli
DOI:
关键词:
摘要: 1 PUBLICATIONS INCLUDED IN THIS THESIS 2 LIST OF ABBREVIATIONS 4 INTRODUCTION 5 General cancer genetics Multistep development –accumulation of genetic and epigenetic changes Oncogenes Tumor Suppressor Genes 6 DNA methylation in 7 Pheochromocytoma abdominal paraganglioma 9 Clinical overview Heritable mutations pheochromocytoma 12 Somatic 13 Chromosomal alterations pheochromocytomas paragangliomas 14 Neuroblastoma 17 Major prognostic factors 18 Germ line neuroblastoma Loss or allelic imbalance the short arm chromosome Amplification MYCN oncogene 19 Gain long 20 Alterations other loci Expression Trk family members Genetic model for progression Candidate genes studied this thesis 21 The Ras effectors RASSF1A NORE1A RIZ1 tumor suppressor 27 p16 AIMS THE PRESENT INVESTIGATION 30 MATERIALS AND METHODS 31 RESULTS DISCUSSION 44 CONCLUSIONS 54 ACKNOWLEDGEMENTS 55 REFERENCES 58
ki.se参考文章(220)
S Khosla, V M Patel, I D Hay, D J Schaid, C S Grant, J A van Heerden, S N Thibodeau, Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas. Journal of Clinical Investigation. ,vol. 87, pp. 1691- 1699 ,(1991) , 10.1172/JCI115186
P. S. White, J. M. Maris, C. Beltinger, E. Sulman, H. N. Marshall, M. Fujimori, B. A. Kaufman, J. A. Biegel, C. Allen, C. Hilliard, A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 5520- 5524 ,(1995) , 10.1073/PNAS.92.12.5520
P.M. Thompson, B.A. Seifried, S.K. Kyemba, S.J. Jensen, C. Guo, J.M. Maris, G.M. Brodeur, D.O. Stram, R.C. Seeger, R. Gerbing, K.K. Matthay, T.C. Matise, P.S. White, Loss of heterozygosity for chromosome 14q in neuroblastoma. Medical and Pediatric Oncology. ,vol. 36, pp. 28- 31 ,(2001) , 10.1002/1096-911X(20010101)36:1<28::AID-MPO1008>3.0.CO;2-0
Larry A. Feig, Rachel J. Buchsbaum, Cell signaling: life or death decisions of ras proteins. Current Biology. ,vol. 12, ,(2002) , 10.1016/S0960-9822(02)00787-X
Yanping Zhang, Yue Xiong, Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Molecular Cell. ,vol. 3, pp. 579- 591 ,(1999) , 10.1016/S1097-2765(00)80351-2
F. M BROUWERS, A. G ELKAHLOUN, P. J MUNSON, G. EISENHOFER, J. BARB, W. M. LINEHAN, J. W.M LENDERS, R. DE KRIJGER, M. MANNELLI, R. UDELSMAN, I. T OCAL, B. L SHULKIN, S. R BORNSTEIN, J. BREZA, L. KSINANTOVA, K. PACAK, Gene expression profiling of benign and malignant pheochromocytoma. Annals of the New York Academy of Sciences. ,vol. 1073, pp. 541- 556 ,(2006) , 10.1196/ANNALS.1353.058
Lois M. Mulligan, Emily Gardner, Barbara A. Smith, Chris G. P. Mathew, Bruce A. J. Ponder, Genetic events in tumour initiation and progression in multiple endocrine neoplasia type 2. Genes, Chromosomes and Cancer. ,vol. 6, pp. 166- 177 ,(1993) , 10.1002/GCC.2870060307
Jo Vandesompele, Frank Speleman, Nadine Van Roy, Genevi�ve Laureys, Christian Brinkschmidt, Holger Christiansen, Fritz Lampert, Maria Lastowska, Nick Bown, Andy Pearson, James C. Nicholson, Fiona Ross, Val�rie Combaret, Olivier Delattre, Bert G. Feuerstein, Dominique Plantaz, Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors: How many genetic subgroups are there? Medical and Pediatric Oncology. ,vol. 36, pp. 5- 10 ,(2001) , 10.1002/1096-911X(20010101)36:1<5::AID-MPO1003>3.0.CO;2-E
W. Tao, A. J. Levine, P19ARF stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 6937- 6941 ,(1999) , 10.1073/PNAS.96.12.6937
M Rydén, R Sehgal, C Dominici, FH Schilling, CF Ibáñez, P Kogner, Expression of mRNA for the neurotrophin receptor trkC in neuroblastomas with favourable tumour stage and good prognosis. British Journal of Cancer. ,vol. 74, pp. 773- 779 ,(1996) , 10.1038/BJC.1996.435