Amorphous aggregate adducts of linker histone H1 turn highly immunologic in the cancers of oesophagus, stomach, gall bladder and ovary
作者： Abdul Rouf Mir , Moinuddin , Safia Habib
DOI: 10.1016/J.IJBIOMAC.2016.12.060
关键词:
摘要: Hyperglycaemic influence on carcinogenesis and tumour progression is emerging as a link between diabetes cancer. This work establishes the disturbed structural integrity of nucleosomal linker histone H1 by methyglyoxal (MG) then correlates role modified in auto-immunopathogenesis multiple cancers. MG modification caused loss free e-amino groups raised its β-sheet component with consequence non amyloid aggregation. It changed folding-unfolding denaturation pattern attached itself to lysine residues protein eventually making up Ne-(carboxyethyl) lysine. The variations act extra antigenic determinants that yield aggressive antibody response, when immunised rabbits. ELISA tests proved immunoglobulin response very specific gel based studies established preferential binding antibodies generated against MG-H1 protein. Cross reaction analysis inferred natures immunoglobulins tendencies different inhibitors. content blood sera derived from human subjects tumours oesophagus, stomach, gall bladder ovary confirmed presence competitive showed their high specificity. may suggest H1, hyperglycaemia, glycoxidation
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sci-hub.se 参考文章(48)
Badar ul Islam, Parvez Ahmad, Gulam Rabbani, Kiran Dixit, Moinuddin, Shahid Ali Siddiqui, Asif Ali, Neo-epitopes on crotonaldehyde modified DNA preferably recognize circulating autoantibodies in cancer patients Tumor Biology. ,vol. 37, pp. 1817- 1824 ,(2016) , 10.1007/S13277-015-3955-4
A. Mir, A. R., Moinuddin, Khan, F., Alam, K. and Ali, Dicarbonyl Induced Structural Perturbations Make Histone H1 Highly Immunogenic and Generate an Auto-Immune Response in Cancer PLOS ONE. ,vol. 10, pp. e0136197- ,(2015) , 10.1371/JOURNAL.PONE.0136197
Sho-ichi Yamagishi, Takanori Matsui, Kei Fukami, Role of receptor for advanced glycation end products (RAGE) and its ligands in cancer risk. Rejuvenation Research. ,vol. 18, pp. 48- 56 ,(2015) , 10.1089/REJ.2014.1625
M Asad Khan, Kiran Dixit, Zarina Arif, Khursheed Alam, None, Studies on peroxynitrite-modified H1 histone: implications in systemic lupus erythematosus. Biochimie. ,vol. 97, pp. 104- 113 ,(2014) , 10.1016/J.BIOCHI.2013.09.026
Mahmoud Melling, Wolfgang Pfeiler, Daniela Karimian-Teherani, Martina Schnallinger, Grazyna Sobal, Christa Zangerle, Ernst J. Menzel, Differential scanning calorimetry, biochemical, and biomechanical analysis of human skin from individuals with diabetes mellitus. Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 259, pp. 327- 333 ,(2000) , 10.1002/1097-0185(20000701)259:3<327::AID-AR90>3.0.CO;2-G
W Makałowski, The human genome structure and organization. Acta Biochimica Polonica. ,vol. 48, pp. 587- 598 ,(2001) , 10.18388/ABP.2001_3893
Kerstin Nowotny, Tobias Jung, Annika Höhn, Daniela Weber, Tilman Grune, Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus Biomolecules. ,vol. 5, pp. 194- 222 ,(2015) , 10.3390/BIOM5010194
Seiji Kikuchi, Kazuyoshi Shinpo, Fumio Moriwaka, Zenji Makita, Toshio Miyata, Kunio Tashiro, Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases. Journal of Neuroscience Research. ,vol. 57, pp. 280- 289 ,(1999) , 10.1002/(SICI)1097-4547(19990715)57:2<280::AID-JNR14>3.0.CO;2-U
Hitoshi Ohmori, Naoki Kanayama, Immunogenicity of an inflammation-associated product, tyrosine nitrated self-proteins. Autoimmunity Reviews. ,vol. 4, pp. 224- 229 ,(2005) , 10.1016/J.AUTREV.2004.11.011
Afshin Iram, Tauqeer Alam, Javed M. Khan, Taqi A. Khan, Rizwan H. Khan, Aabgeena Naeem, Molten Globule of Hemoglobin Proceeds into Aggregates and Advanced Glycated End Products PLoS ONE. ,vol. 8, pp. e72075- ,(2013) , 10.1371/JOURNAL.PONE.0072075