Neural progenitor diversity and their therapeutic potential for spinal cord repair
作者： Hedong Li , Wei Shi
DOI: 10.1007/S11515-010-0830-Y
关键词:
摘要: Development of the central nervous system (CNS) requires progressive differentiation neural stem cells, which generate a variety progenitors with distinct properties and potentials in spatiotemporally restricted manner. The underlying mechanisms progenitor diversification during development started to be unraveled over past years. We have addressed these questions by v-myc immortalization method generation clones. These clones are served as vitro models cellular tools for transplantation animal neurological disorders including spinal cord injury. In this review, we will discuss features two types (radial glia GABAergic interneuron progenitor) even within each type. also pathophysiology injury our ongoing research address both motor sensory malfunctions progenitors.
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Isabelle Pineau, Steve Lacroix, Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved The Journal of Comparative Neurology. ,vol. 500, pp. 267- 285 ,(2007) , 10.1002/CNE.21149
Nico Heins, Paolo Malatesta, Francesco Cecconi, Masato Nakafuku, Kerry Lee Tucker, Michael A. Hack, Prisca Chapouton, Yves-Alain Barde, Magdalena Götz, Glial cells generate neurons: the role of the transcription factor Pax6 Nature Neuroscience. ,vol. 5, pp. 308- 315 ,(2002) , 10.1038/NN828
Qi-Lin Cao, Russell M Howard, Jessica B Dennison, Scott R Whittemore, Differentiation of engrafted neuronal-restricted precursor cells is inhibited in the traumatically injured spinal cord. Experimental Neurology. ,vol. 177, pp. 349- 359 ,(2002) , 10.1006/EXNR.2002.7981
Karen B. Larsen, Melissa C. Lutterodt, Henning Laursen, Niels Græm, Bente Pakkenberg, Kjeld Møllgård, Morten Møller, Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain. Developmental Neuroscience. ,vol. 32, pp. 149- 162 ,(2010) , 10.1159/000297602
G. Miyoshi, S. J. B. Butt, H. Takebayashi, G. Fishell, Physiologically Distinct Temporal Cohorts of Cortical Interneurons Arise from Telencephalic Olig2-Expressing Precursors The Journal of Neuroscience. ,vol. 27, pp. 7786- 7798 ,(2007) , 10.1523/JNEUROSCI.1807-07.2007
Jun Yan, Annie M. Welsh, Susan H. Bora, Evan Y. Snyder, Vassilis E. Koliatsos, Differentiation and tropic/trophic effects of exogenous neural precursors in the adult spinal cord. The Journal of Comparative Neurology. ,vol. 480, pp. 101- 114 ,(2004) , 10.1002/CNE.20344
L PINTO, M GOTZ, Radial glial cell heterogeneity--the source of diverse progeny in the CNS. Progress in Neurobiology. ,vol. 83, pp. 2- 23 ,(2007) , 10.1016/J.PNEUROBIO.2007.02.010
Dale Woodbury, Emily J. Schwarz, Darwin J. Prockop, Ira B. Black, Adult rat and human bone marrow stromal cells differentiate into neurons Journal of Neuroscience Research. ,vol. 61, pp. 364- 370 ,(2000) , 10.1002/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C
Magdalena Götz, Anastassia Stoykova, Peter Gruss, Pax6 Controls Radial Glia Differentiation in the Cerebral Cortex Neuron. ,vol. 21, pp. 1031- 1044 ,(1998) , 10.1016/S0896-6273(00)80621-2
Carl P. Wonders, Stewart A. Anderson, The origin and specification of cortical interneurons Nature Reviews Neuroscience. ,vol. 7, pp. 687- 696 ,(2006) , 10.1038/NRN1954