Role of high-, low- and very low-density lipoproteins in the transport and tumor-delivery of hematoporphyrin in vivo.
作者： A. Barel , G. Jori , A. Perin , P. Romandini , A. Pagnan
DOI: 10.1016/0304-3835(86)90112-6
关键词:
摘要: Free hematoporphyrin administered intravenously to healthy rabbits (1-28 mg/kg body weight) is bound by the 3 major lipoprotein components of plasma (VLDL, LDL and HDL) with different efficiency. In vitro-prepared complexes (Hp) fractions isolated from mouse serum have been injected intracardiacally into mice affected MS-2 fibrosarcoma (1 mg Hp per kg weight). appear allow a more specific delivery complexed tumor tissue as compared HDL, VLDL or free Hp. The behavior VLDL, HDL carriers in vivo also discussed.
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