Randomized Trial Comparing Cyclophosphamide, Epirubicin, and Fluorouracil With Cyclophosphamide, Methotrexate, and Fluorouracil in Premenopausal Women With Node-Positive Breast Cancer: Update of National Cancer Institute of Canada Clinical Trials Group Trial MA5
作者： Mark N. Levine , Kathleen I. Pritchard , Vivien H.C. Bramwell , Lois E. Shepherd , Dongsheng Tu
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摘要: Purpose Certain anthracycline-containing adjuvant chemotherapy regimens are associated with improved relapse-free survival (RFS) and overall (OS) compared the classic regimen of cyclophosphamide, methotrexate, fluorouracil in women early-stage breast cancer. Patients Methods Between 1989 1993, 710 pre- perimenopausal axillary node–positive cancer were randomly assigned to either cyclophosphamide 75 mg/m2 orally days 1 through 14, epirubicin 60 intravenously 8, 500 8 (CEF) or CMF (cyclophosphamide 100 methotrexate 40 600 8). On basis follow-up May 1997 (median time, 59 months), there was a statistically significant improvement RFS OS for CEF CMF. Results The trial results now updated, median 10 years live patie...
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