Zika Virus Associated with Microcephaly

摘要: Summary A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 South and Central America the Caribbean. major concern associated with this is apparent increased incidence microcephaly fetuses born to mothers infected ZIKV. In report, we describe case an expectant mother who had a febrile illness rash at end first trimester pregnancy while she living Brazil. Ultrasonography performed 29 weeks gestation revealed calcifications fetal brain placenta. After requested termination pregnancy, autopsy performed. Micrencephaly (an abnormally small brain) observed, almost complete agyria, hydrocephalus, multifocal dystrophic cortex subcortical white matter, cortical displacement mild focal inflammation. ZIKV found tissue on reversetranscriptase–polymerase-chain-reaction (RT-PCR) assay, consistent findings electron microscopy. The genome recovered from brain.