The Role of microRNAs in Drug Addiction: A Big Lesson from Tiny Molecules
作者： Andrzej Zbigniew Pietrzykowski
DOI: 10.1016/S0074-7742(10)91001-5
关键词:
摘要: Alcoholism is a multifactorial disease of unclear molecular underpinnings. Currently, we are witnessing major shift in our understanding the functional elements genome, which could help us to discover novel insights into nature alcoholism. In humans, vast majority genome encodes non-protein-coding DNA with function. Recent research has started unveil this mystery by describing relevance microRNAs, and examining genes regulated DNA. Here, I describe alcohol regulation microRNAs provide examples that control expression alcohol-relevant genes. Emphasis put on potential explaining polygenic alcoholism prospects microRNA future directions burgeoning field.
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John P. Cogswell, James Ward, Ian A. Taylor, Michelle Waters, Yunling Shi, Brian Cannon, Kevin Kelnar, Jon Kemppainen, David Brown, Caifu Chen, Rab K. Prinjha, Jill C. Richardson, Ann M. Saunders, Allen D. Roses, Cynthia A. Richards, Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways Journal of Alzheimer's Disease. ,vol. 14, pp. 27- 41 ,(2008) , 10.3233/JAD-2008-14103
Marjorie P Perron, Patrick Provost, Protein interactions and complexes in human microRNA biogenesis and function Frontiers in Bioscience. ,vol. 13, pp. 2537- 2547 ,(2008) , 10.2741/2865
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Yuliang Tan, Bo Zhang, Tao Wu, Geir Skogerbo, Xiaopeng Zhu, Xiangqian Guo, Shunmin He, Runsheng Chen, Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells. BMC Molecular Biology. ,vol. 10, pp. 12- 12 ,(2009) , 10.1186/1471-2199-10-12
Thomas Sander, David Ball, Robin Murray, Jaimin Patel, Jerzy Samochowiec, Georg Winterer, Hans Rommelspacher, Lutz G. Schmidt, El-Wui Loh, Association Analysis of Sequence Variants of the GABAAα6, β2, and γ2 Gene Cluster and Alcohol Dependence Alcoholism: Clinical and Experimental Research. ,vol. 23, pp. 427- 431 ,(1999) , 10.1111/J.1530-0277.1999.TB04133.X
Cindy L. Ehlers, Variations in ADH and ALDH in Southwest California Indians. Alcohol Research & Health. ,vol. 30, pp. 14- 17 ,(2007)
Christine Windemuth, Andreas Hahn, Konstantin Strauch, Max P. Baur, Thomas F. Wienker, Linkage analysis in alcohol dependence. Genetic Epidemiology. ,vol. 17, ,(1999) , 10.1002/GEPI.1370170768
Hua Hu, Li-Rong Shao, Sorush Chavoshy, Ning Gu, Maria Trieb, Ralf Behrens, Petter Laake, Olaf Pongs, Hans Günther Knaus, Ole Petter Ottersen, Johan F. Storm, Presynaptic Ca2+-Activated K+Channels in Glutamatergic Hippocampal Terminals and Their Role in Spike Repolarization and Regulation of Transmitter Release The Journal of Neuroscience. ,vol. 21, pp. 9585- 9597 ,(2001) , 10.1523/JNEUROSCI.21-24-09585.2001
Attila Molnar, Andrew Bassett, Eva Thuenemann, Frank Schwach, Shantanu Karkare, Stephan Ossowski, Detlef Weigel, David Baulcombe, Highly specific gene silencing by artificial microRNAs in the unicellular alga Chlamydomonas reinhardtii Plant Journal. ,vol. 58, pp. 165- 174 ,(2009) , 10.1111/J.1365-313X.2008.03767.X
Irene Guerrini, Christopher CH Cook, Wendy Kest, Audrey Devitgh, Andrew McQuillin, David Curtis, Hugh MD Gurling, Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2. BMC Genetics. ,vol. 6, pp. 11- 11 ,(2005) , 10.1186/1471-2156-6-11