aPKCλ/ι promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
作者： H. Ishiguro , K. Akimoto , Y. Nagashima , Y. Kojima , T. Sasaki
关键词:
摘要: Understanding the mechanism by which hormone refractory prostate cancer (HRPC) develops remains a major issue. Alterations in HRPC include androgen receptor (AR) changes. In addition, AR is activated cytokines such as interleukin-6 (IL-6). Atypical protein kinase C (aPKCλ/ι) has been implicated progression of several cancers. Herein, we provide evidence that aPKCλ/ι expression correlates with recurrence. Experiments vitro and vivo revealed to be involved cell growth through secretion IL-6. Further, activates transcription IL-6 gene NFκB AP-1. We conclude promotes independent cells stimulating production an autocrine manner. Our findings not only explain link between IL-6, variety cancers, but also establish molecular change development HRPC. might biomarker for progression.
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