CYP2E1 and NQO1 genotypes and bladder cancer risk in a Lebanese population.
作者： Hassan R Dhaini , Loulou H Kobeissi , Michel E Jabbour , Hussein A Basma , Mohamad A Moussa
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摘要: Urinary bladder cancer incidence in Lebanon ranks among the highest world. Cytochrome P450 2E1 (CYP2E1), NAD(P)H quinone oxidoreductase1 (NQO1), and N-Acetyltransferase1 (NAT1), are drug-metabolizing enzymes (DMEs) involved metabolism of carcinogens, such as arylamines heterocyclic amines, implicated cancer. The present study attempts to investigate role these DMEs genetic polymorphism risk Lebanese men. 54 cases 106 controls were recruited from two hospitals Beirut. An interview-based questionnaire was administered assess suspected environmental occupational factors. PCR-RFLP performed on blood-based DNA samples determine genotypes. Associations between putative factors measured using adjusted odds ratios (ORs) their 95% confidence intervals (CIs). Results showed CYP2E1 c1/c1, NAT1*14A, smoking, be for No significant differences frequency distribution NQO1 genotypes found versus controls. carrying c1/c1 genotype 4 times higher compared (OR=3.97, CI: 0.48-32.7). at least one NAT1*14A allele 14 (OR=14.4, 1.016-204.9). Our suggests potential Lebanese. Further studies with larger must conducted confirm findings.
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