PTEN Loss in Gleason Score 3 + 4=7 Prostate Biopsies is Associated with Nonorgan Confined Disease at Radical Prostatectomy
作者： Liana B. Guedes , Jeffrey J. Tosoian , Jessica Hicks , Ashley E. Ross , Tamara L. Lotan
DOI: 10.1016/J.JURO.2016.09.084
关键词:
摘要: Purpose: Men with intermediate risk prostate cancer have widely variable outcomes. Some suggest that active surveillance or less invasive therapies (brachytherapy focal therapy) may be appropriate for some men Gleason score 3 + 4 = 7 disease. Molecular markers help further distinguish cancers aggressive behavior. We tested whether loss of the PTEN (phosphatase and tensin homolog) tumor suppressor in biopsies is associated adverse pathology at prostatectomy.Materials Methods: queried needle from 2000 to 2014 a maximum followed by prostatectomy. A total 260 cases had status evaluable clinical grade immunohistochemistry. Biopsy was correlated preoperative postoperative clinicopathological parameters.Results: detected 27% biopsies. Loss common tumors African American compared European (9% vs 31%, p 0.0...
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