Prospects for a dengue virus vaccine

摘要: The number of cases severe dengue disease continues to grow in endemic areas southeast Asia, Central and South America, other subtropical regions. Children bear the greatest burden disease, development an effective vaccine remains a global public health priority. A tetravalent is urgently needed must be against all four virus serotypes, cost-effective provide long-term protection. In this Review we discuss unique immunological concerns current prospects for acceptable vaccine, goal that likely reached near future.