The Role of Orbital Radiotherapy in the Management of Thyroid Related Orbitopathy

摘要: The treatment protocol for orbital radiotherapy published in 1973 by Donaldson et al. has been adopted all radation oncology centers worldwide Patients are presently exposed to a total of 20 Gy delivered ten fractional sessions with the beam directed at retro-ocular tissues,posteriorly 5°, avoid excessive exposure retina and lens While there is no clear understanding mechanism which low-dose radiation modulates local inflammatory response orbit, number vitro studies provide evidence suggest multiple mechanisms currently held model thyroid associated orbitopathy may be modified blunt downstream consequences fibroblast activation The majority patients suffering Graves’ not candidates radiotherapy Patients mild disease or stable phase will benefit from when compared natural history disease In more severely affected patients, reversal optic neuropathy, improvement extraocular motility decrease congestive signs symptoms can anticipated after