Anxiety Sensitivity As Moderator of the Association Between Nicotine withdrawal and Panic-Relevant Responding to a Carbon Dioxide-Enriched Air Laboratory Challenge

摘要: Individuals high in anxiety sensitivity (AS), a cognitive risk factor denoting fear of anxiety-related sensations (Reiss & McNally, 1985), may be at increased misinterpreting nicotine withdrawal-relevant interoceptive cues as harmful, thus amplifying their for panic problems. This study tested the moderating role AS on association between withdrawal and panic-relevant responding to carbon dioxide-enriched air laboratory challenge. Specifically, it was hypothesized that moderates relation (group status) procedure (controlling anticipatory anxiety, gender, negative affectivity, number axis I diagnoses, average daily smoking rate), indexed by: (1) level focused bodily intensity attack symptoms; (2) skin conductance reactivity; (3) behavioral avoidance future To test this hypothesis, 90 smokers (35 women; Mage = 28.87, SD 12.12, Range 18-60 years) were enrolled enlisted attend two sessions. At conclusion first session, participants randomly assigned one groups (12-hour deprivation or usual‘). second scheduled both underwent 10% challenge assess responding. Contrary by interactive effect not significantly predictive post-challenge symptoms, reactivity, avoidance. However, post hoc tests indicated interaction peri-challenge ratings. Furthermore, demonstrated between-group (significant) differences symptoms diminished after assessment session. Results are discussed context theoretical clinical implications current work, limitations study, directions work relevant line inquiry.