Age variations in the properties of human tibial trabecular bone and cartilage

摘要: Initiated and motivated by clinical scientific problems such as age-related bone fracture, prosthetic loosening, remodeling, degenerative diseases, much significant research on the properties of trabecular has been carried out over last two decades. This work mainly focused central vertebral bone, while little is known about changes in human peripheral (tibial) bone. Knowledge major importance for understanding diseases osteoarthrosis osteoporosis, design, fixation durability total joint prosthesis. The specific aims present studies were: 1) to investigate normal variations mechanical, physical/compositional, structural tibial bone; 2) osteoarthrosis-related mechanical cartilage-bone complex; 3) evaluate mutual associations among various properties. Normal specimens from autopsy proximal tibiae were used investigation age complex, osteoarthrotic complex induced this disease process. physical/compositional quantified means standard techniques, structure was unbiased three-dimensional methods. study demonstrated that properties, Young's modulus, ultimate stress, strain failure energy, densities, apparent, apparent ash collagen densities have relationships with age. Tissue density mineral concentration remain constant throughout life. Trabecular tougher younger age, i.e. fracture requires more energy. Collagen single best predictor only strain. decrease a consequence loss substance. showed degree anisotropy (preferential orientation trabeculae), mean marrow space volume, surface-to-volume ratio increased significantly Bone volume fraction, surface decreased Connectivity did not general relationship yet trend exists. Age-related microstructural had same trends both medial lateral condyles tibia. observed increase may be interpreted adaptation secondary age-induced loss. aging trabeculae align strongly primary direction, which parallel longitudinal loading axis cartilage vary respond simultaneously loading. Both early-stage OA are mechanically inferior normal, lost their unit function