Is Thyroid Inadequacy During Gestation a Risk Factor for Adverse Pregnancy and Developmental Outcomes?

摘要: A workshop entitled, "The Impact of Maternal Thyroid Diseases on the Developing Fetus: Implications for Diagnosis, Treatment, and Screening," was held in Atlanta, Georgia, January 12-13, 2004. This paper reports individual session that examined thyroid inadequacy during gestation as a risk factor adverse pregnancy developmental outcomes. For this following papers were presented: "Adverse Pregnancy Outcomes"; "Thyroid Physiology Fetus"; "New England Data: Cretinism Revisited-Preventing Fetal Brain Damage when Mothers Have Subclinical Hypothyroidism"; "Dutch Pregnancy, (Dys)function Outcome Offspring"; "Report Wales Controlled Antenatal Screening Study (CATS); Prospective RCT." These presentations formally discussed by invited respondents well others attendance. Salient points from about which there agreement include following. hypothyroidism is associated with complications effects fetus. risks are greater women overt compared to subclinical hypothyroidism, also appear be increased euthyroid autoimmune disease. If maternal treated adequately, appears reduce The demonstration pattern ontogeny fetal cerebral cortex deiodinases hormone receptors, beginning 7-8 weeks' gestation, circumstantial evidence plays an important role neurodevelopment. Significant production secretion does not begin until approximately 20 gestation. significant neurodevelopment before it likely origin. Studies demonstrate low levels thyroxine coelomic fluid blood prior 12-14 Published data consistently document relationship between deficiency problems neuropsychological development offspring.