Sexy Transgenes: the Impact of Gene Transfer and Gene Inactivation Technologies on the Understanding of Mammalian Sex Determination

摘要: Amongst the various developmental pathways ending in a sound mammal, sex determination presents peculiarity of choice between two equally viable options: female or male. Therefore, destroying ‘male-determining gene’ ‘female-determining should generally not be lethal. Genetic is divided into consecutive steps: construction bipotential gonad, and then per se. The genes involved first step are fact development body compartments, their mutation far from innocuous. From transgenic inactivation studies carried out on laboratory mouse, complete picture steps beginning to emerge, where gonad itself necessary ducts shown evolve very coordinate way, with well-defined sex-specificities. Compared testis determination, ovarian side still relatively empty, but this situation can change rapidly as candidate for identified.