Description and nomenclature of Neisseria meningitidis capsule locus.

摘要: Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of structure responsible serogroup specificity. Molecular mechanisms involved in N. biosynthesis also identified, genes process cell surface translocation are clustered at single chromosomal locus termed cps. The use multiple names some synthesis, combined with need rapid diagnosis serogroups commonly associated invasive meningococcal disease, prompted requirement consistent approach to nomenclature genes. In report, comprehensive description all provided, along proposed nomenclature, which was presented 2012 XVIIIth International Conference.