The impacts of bisphenol A (BPA) on abalone (Haliotis diversicolor supertexta) embryonic development.
作者： Jin Zhou , Xiao-Shan Zhu , Zhong-Hua Cai
DOI: 10.1016/J.CHEMOSPHERE.2010.09.056
关键词:
摘要: The effects of bisphenol A (BPA) on abalone (Haliotis diversicolor supertexta) embryonic development were investigated by exposing the fertilized eggs to four different concentrations BPA (0.05, 0.2, 2 and 10 μg mL(-1)). Toxicity endpoints including embryo parameters, physiological features expression profile several reference genes (prohormone convertase 1, PC1; cyclin B, CB; cyclin-dependent kinase CDK1) assessed. results showed that could markedly reduce hatchability, increase developmental malformation, suppress metamorphosis behavior larvae. possible toxicological mechanisms hidden behind these (i.e. disturbing embryogenesis) might result from three aspects: (1) disturbance cellular ionic homeostasis osmoregulation embryos changing Na+-K+-ATPase Ca2+-Mg2+-ATPase levels; (2) induced oxidative damage significantly altering peroxidase (POD) activities malondialdehyde (MDA) production; (3) RT-PCR analysis further demonstrated perturbed endocrine regulation cell cycle progression down-regulating PC1 gene, as well over-expressing CB CDK1 genes. This is first comprehensive study toxicity marine at morphological, molecular levels. in this also indicated tests can contribute ecological risk assessment disruptors environment.
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Han Na Kim, Kyeong Seo Park, Sung Kyu Lee, Man Bock Gu, Gene Expression Characteristics in the Japanese Medaka (Oryzias latipes) Liver after Exposure to Endocrine Disrupting Chemicals Advanced Environmental Monitoring. pp. 338- 347 ,(2008) , 10.1007/978-1-4020-6364-0_26
Tsutomu Shioda, Meiko Wakabayashi, Effect of certain chemicals on the reproduction of medaka () Chemosphere. ,vol. 40, pp. 239- 243 ,(2000) , 10.1016/S0045-6535(99)00235-0
Gerold Schubiger, Cory Trusty, Jun-Yuan Ji, Susanne Trautmann, Lisa A. Stiffler, Cyclin A and B functions in the early Drosophila embryo. Development. ,vol. 126, pp. 5505- 5513 ,(1999) , 10.1242/DEV.126.23.5505
Laurent Richard-Parpaillon, Ruth A Cosgrove, Christine Devine, Ann E Vernon, Anna Philpott, G1/S phase cyclin-dependent kinase overexpression perturbs early development and delays tissue-specific differentiation in Xenopus. Development. ,vol. 131, pp. 2577- 2586 ,(2004) , 10.1242/DEV.01121
Haifang Li, Wei Lin, Guang Zhang, Zhonghua Cai, Guopin Cai, Yaqing Chang, Kezhi Xing, Enhancement of larval settlement and metamorphosis through biological and chemical cues in the abalone Haliotis diversicolor supertexta Aquaculture. ,vol. 258, pp. 416- 423 ,(2006) , 10.1016/J.AQUACULTURE.2006.04.013
M. Schirling, A. Bohlen, R. Triebskorn, H.-R. Köhler, An invertebrate embryo test with the apple snail Marisa cornuarietis to assess effects of potential developmental and endocrine disruptors. Chemosphere. ,vol. 64, pp. 1730- 1738 ,(2006) , 10.1016/J.CHEMOSPHERE.2006.01.015
Nicolas Escoffier, Julien Gaudin, Karim Mezhoud, Hélène Huet, Sophie Chateau-Joubert, Jean Turquet, François Crespeau, Marc Edery, Toxicity to medaka fish embryo development of okadaic acid and crude extracts of Prorocentrum dinoflagellates. Toxicon. ,vol. 49, pp. 1182- 1192 ,(2007) , 10.1016/J.TOXICON.2007.02.008
Masato Kiyomoto, Ayumi Kikuchi, Tatuya Unuma, Yukio Yokota, Effects of ethynylestradiol and bisphenol A on the development of sea urchin embryos and juveniles Marine Biology. ,vol. 149, pp. 57- 63 ,(2006) , 10.1007/S00227-005-0208-X
T Masaki, Hepatocellular Carcinoma Cell Cycle: Study of Long-Evans Cinnamon Rats Hepatology. ,vol. 32, pp. 711- 720 ,(2000) , 10.1053/JHEP.2000.17705
Rie HANDO, Mitsuru ABO, Akira OKUBO, Determination of alkylphenols and bisphenol A in sea environment by GC/MS Bunseki Kagaku. ,vol. 52, pp. 695- 699 ,(2003) , 10.2116/BUNSEKIKAGAKU.52.695