A Bio-Acoustic Levitational (BAL) Assembly Method for Engineering of Multilayered, 3D Brain-Like Constructs, Using Human Embryonic Stem Cell Derived Neuro-Progenitors

作者: Charlène Bouyer , Pu Chen , Sinan Güven , Tuğrul Tolga Demirtaş , Thomas J. F. Nieland

DOI: 10.1002/ADMA.201503916

关键词:

摘要: A bio-acoustic levitational assembly method for engineering of multilayered, 3D brainlike constructs is presented. Acoustic radiation forces are used to levitate neuroprogenitors derived from human embryonic stem cells in multilayered fibrin tissue constructs. The neuro-progenitor subsequently differentiated neural cells, resulting a neuronal construct with inter and intralayer neurite elongations.

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