Cell adhesion integrins as pharmaceutical targets

摘要: The leukocyte integrins are transmembrane receptors expressed on circulating white blood cells that regulate their adhesion to other cells, the extracellular matrix, soluble proteins, and pathogens. Leukocyte adhesiveness is dynamically regulated in response various cellular stimuli such as exposure chemoattractants cross-linking of B T cell receptors. capacity modulate integrin prevents from non-specific attachment absence specific inflammatory signals allows them detach vessel wall migrate into tissue.