Nuclear Import and Export Signals

作者: Toshihiro Sekimoto , Jun Katahira , Yoshihiro Yoneda

DOI: 10.1007/0-387-27747-1_4

关键词:

摘要: Eukaryotic cells are separated into two large compartments, namely the nucleus and cytoplasm, by nuclear envelope. As a result, macromolecules including RNAs, which transcribed in proteins, translated cytoplasm must cross double Upid bilayer to reach intracellular sites where they function. In addition, cumulative evidence suggests that trafficking between is rather dynamic some proteins RNAs envelope again after being transported one compartment.

参考文章(99)
Arie Kaffman, Nicole Miller Rank, Elizabeth M. O'Neill, Linda S. Huang, Erin K. O'Shea, The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus Nature. ,vol. 396, pp. 482- 486 ,(1998) , 10.1038/24898
T. T. Huang, N. Kudo, M. Yoshida, S. Miyamoto, A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 1014- 1019 ,(2000) , 10.1073/PNAS.97.3.1014
N. Imamoto, T. Shimamoto, T. Takao, T. Tachibana, S. Kose, M. Matsubae, T. Sekimoto, Y. Shimonishi, Y. Yoneda, In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. The EMBO Journal. ,vol. 14, pp. 3617- 3626 ,(1995) , 10.1002/J.1460-2075.1995.TB00031.X
Makoto Fukuda, Shiro Asano, Takahiro Nakamura, Makoto Adachi, Minoru Yoshida, Mitsuhiro Yanagida, Eisuke Nishida, None, CRM1 is responsible for intracellular transport mediated by the nuclear export signal Nature. ,vol. 390, pp. 308- 311 ,(1997) , 10.1038/36894
Lan Xu, Ye-Guang Chen, Joan Massagué, The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation. Nature Cell Biology. ,vol. 2, pp. 559- 562 ,(2000) , 10.1038/35019649
D. Görlich, P. Henklein, R. A. Laskey, E. Hartmann, A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus. The EMBO Journal. ,vol. 15, pp. 1810- 1817 ,(1996) , 10.1002/J.1460-2075.1996.TB00530.X
U. Zabel, T. Henkel, M.S. Silva, P.A. Baeuerle, Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus The EMBO Journal. ,vol. 12, pp. 201- 211 ,(1993) , 10.1002/J.1460-2075.1993.TB05646.X
Wei Wen, Judy L Meinkotht, Roger Y Tsien, Susan S Taylor, Identification of a signal for rapid export of proteins from the nucleus Cell. ,vol. 82, pp. 463- 473 ,(1995) , 10.1016/0092-8674(95)90435-2