Kidney, heart and brain: three organs targeted by ageing and glycation

摘要: Advanced glycation end-product (AGE) is the generic term for a heterogeneous group of derivatives arising from non-enzymatic reaction between reducing sugars and proteins. In recent years, evidence has accumulated that incriminates AGEs in pathogenic processes associated with both chronic hyperglycaemia age-related diseases. Regardless their exogenous or endogenous origin, accumulation could promote accelerated ageing by leading to protein modifications activating several inflammatory signalling pathways via AGE-specific receptors. However, it remains be demonstrated whether preventing effects an important therapeutic option successful ageing. The present review gives overview current knowledge on role focusing three AGE target organs: kidney, heart brain. For each these organs we concentrate disease, which major public health issue: kidney dysfunction neurodegenerative Even though strong connections have been highlighted pathogenesis, causal links still need validated. case, report uncertainties suggested animal epidemiological studies possible link pathogenesis hyperglycaemic state, absence diabetes, alone. Finally, some promising anti-AGE strategies are currently being studied.